Understanding how genetic variations affect immune system diseases
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune tolerance
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11001217
This study is looking at how a part of your immune system called interleukin-2 and its receptor work, especially in people who might be more likely to develop autoimmune diseases like allergic asthma and lupus, to help us understand why some people get these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11001217 on ClinicalTrials.gov |
What this research studies
This research investigates the role of interleukin-2 and its receptor in regulating immune responses and self-tolerance. By examining genetic variations that influence susceptibility to autoimmune diseases like allergic asthma and lupus, the study aims to uncover the mechanisms behind these conditions. Using advanced techniques such as ATAC-seq and CRISPR/Cas9 genome editing, researchers will explore how specific genetic elements affect the expression of IL2 and IL2RA, which are crucial for immune function. Patients with certain genetic profiles may be analyzed to better understand their immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic variations linked to autoimmune diseases such as allergic asthma, systemic lupus erythematosus, and inflammatory bowel disease.
Not a fit: Patients without genetic variations associated with immune-mediated diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the prevention and treatment of autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding immune responses through genetic studies, indicating that this approach has potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WELLS, ANDREW D — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: WELLS, ANDREW D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.