Understanding how genetic variations affect human traits and diseases
Official title: Perturbation-response approaches to determining the regulatory networks underlying human complex traits
Funded at University of Pennsylvania · NIH-11169372 · Data updated 2026-11-12
This study is looking at how changes in our genes can lead to health problems, with the goal of finding better ways to treat common diseases by understanding how to fix those gene changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 18, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HG012373-03 |
| Project ID | NIH-11169372 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heritable complex traits or diseases that may be influenced by genetic variations.
✕Less likely to help
Patients with purely environmental or non-genetic conditions may not benefit from this research.
What this research studies
This research investigates the complex genetic networks that contribute to human traits and diseases, focusing on how disruptions in these networks can lead to health issues. By utilizing advanced computational methods and large-scale genetic data, the project aims to identify regulatory changes that underlie common diseases. The approach includes improving methods for causal structure learning and integrating various data sources to construct a comprehensive causal network. This could ultimately help in developing targeted treatments by revealing how to restore normal gene function.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for complex diseases by identifying key genetic regulatory mechanisms.
How similar studies have gone: Previous research has shown promise in using similar computational approaches to understand genetic networks, indicating potential for success in this novel application.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Brown, Brielin — University of Pennsylvania
- Study coordinator: Brown, Brielin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.