Understanding how genetic variations affect human traits and diseases
Perturbation-response approaches to determining the regulatory networks underlying human complex traits
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11169372
This study is looking at how changes in our genes can lead to health problems, with the goal of finding better ways to treat common diseases by understanding how to fix those gene changes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11169372 on ClinicalTrials.gov |
What this research studies
This research investigates the complex genetic networks that contribute to human traits and diseases, focusing on how disruptions in these networks can lead to health issues. By utilizing advanced computational methods and large-scale genetic data, the project aims to identify regulatory changes that underlie common diseases. The approach includes improving methods for causal structure learning and integrating various data sources to construct a comprehensive causal network. This could ultimately help in developing targeted treatments by revealing how to restore normal gene function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heritable complex traits or diseases that may be influenced by genetic variations.
Not a fit: Patients with purely environmental or non-genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for complex diseases by identifying key genetic regulatory mechanisms.
How similar studies have performed: Previous research has shown promise in using similar computational approaches to understand genetic networks, indicating potential for success in this novel application.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROWN, BRIELIN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BROWN, BRIELIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.