Understanding how genetic variations affect DNA interactions with transcription factors
Dissecting natural variation in transcription factor - DNA interactions
This study is looking at how changes in our genes and their chemical tags affect how proteins called transcription factors attach to DNA, which is important for controlling how our genes work, and the findings could help us understand more about diseases related to these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10847523 on NIH RePORTER |
What this research studies
This research investigates how variations in the genome and epigenome influence the binding of transcription factors to DNA, which is crucial for regulating gene expression. By analyzing the binding patterns of transcription factors, the study aims to uncover the underlying mechanisms that lead to differences in gene regulation and phenotypic diversity. The approach includes generating detailed maps of DNA modifications and using computational analysis to interpret these interactions. Patients may benefit from insights gained about how genetic variations contribute to diseases linked to transcription factor binding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations that may affect transcription factor binding and are linked to specific diseases.
Not a fit: Patients without significant genetic variations or those not affected by diseases related to transcription factor binding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors that influence disease susceptibility and treatment responses.
How similar studies have performed: Previous studies have successfully characterized transcription factor binding in model organisms, suggesting that this approach may yield valuable insights in humans as well.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Huang, Shao-Shan Carol — New York University
- Study coordinator: Huang, Shao-Shan Carol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.