Understanding how genetic variations affect cell behavior and traits
A quantitative examination of cellular mechanisms that modulate the impacts of genetic variation - Renewal - 1
['FUNDING_OTHER'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-11088680
This study looks at how changes in genes can affect how cells behave, using yeast to see how these changes impact cell growth and function in different situations, with the hope of finding ways to improve medical treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (TEMPE, UNITED STATES) |
| Trial ID | NIH-11088680 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic mutations influence the characteristics of cells, particularly focusing on the effects of misfolded proteins and their interactions with various cellular features. By using budding yeast as a model organism, the research employs high-throughput experiments to gather extensive data on how mutations affect cell growth and behavior across different environments. The goal is to develop predictive models that can help understand the complex relationships between genetic variations and their phenotypic outcomes, which could ultimately inform medical treatments and interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations that may lead to abnormal protein folding and related health issues.
Not a fit: Patients with conditions unrelated to genetic mutations or protein folding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved predictions of how genetic mutations affect health, potentially guiding personalized medicine approaches.
How similar studies have performed: Previous research has shown promise in using model organisms to understand genetic impacts on phenotypes, indicating that this approach could yield valuable insights.
Where this research is happening
TEMPE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — TEMPE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GEILER-SAMEROTTE, KERRY A — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: GEILER-SAMEROTTE, KERRY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.