Understanding how genetic variations affect brain imaging in Alzheimer's disease
Bridging the gap between genetic variants and radiomic phenotypes via genomic large language models
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10948002
This study is looking at how certain genes might affect brain changes in people with Alzheimer's, using smart technology to help find better ways to diagnose and treat the disease based on individual genetic information.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10948002 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between genetic variants and brain imaging traits in Alzheimer's disease using advanced artificial intelligence techniques. By developing genomic large language models, the study aims to decode how specific genetic changes influence the biological processes that lead to Alzheimer's. Patients may benefit from improved diagnostic tools and personalized treatment strategies based on their genetic profiles. The research will involve analyzing genetic data alongside brain imaging results to uncover these relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with non-genetic forms of dementia or those without a familial history of Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and targeted therapies for Alzheimer's disease based on individual genetic information.
How similar studies have performed: Previous research has shown promise in using artificial intelligence to analyze genetic data, suggesting that this approach could yield significant insights into Alzheimer's disease.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, QIAO — STANFORD UNIVERSITY
- Study coordinator: LIU, QIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease