Understanding how genetic variations affect brain function in Alzheimer's disease
Modeling the impact of regulatory and splicing variants on cellular function in Alzheimer's disease
This study is looking at how differences in our genes might affect brain health and contribute to Alzheimer's disease, so that people can better understand their own risk and find new ways to help prevent or treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11051243 on NIH RePORTER |
What this research studies
This research investigates the role of genetic variations in the development of Alzheimer's disease (AD), focusing on how these variations impact cellular functions related to brain health. By analyzing genetic data and using advanced techniques like human induced pluripotent stem cells (hiPSCs), the team aims to identify specific genetic factors that contribute to AD. Patients may benefit from insights into how their genetic makeup influences their risk for AD and potential new therapeutic targets. The study employs a combination of statistical analysis and cellular models to explore these genetic influences.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with non-genetic forms of dementia or those without any familial link to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting specific genetic factors.
How similar studies have performed: Previous research has shown promise in understanding genetic contributions to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Raj, Towfique — Icahn School of Medicine at Mount Sinai
- Study coordinator: Raj, Towfique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.