Understanding how genetic variation affects traits and disease risk
Polygenic prediction and evolution of complex traits
This study looks at how our genes can change over time and affect our traits, helping us understand how these changes might influence health risks in different people, so we can better predict health outcomes for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11011159 on NIH RePORTER |
What this research studies
This research investigates the genetic variations that lead to differences in traits among individuals, focusing on how these variations are influenced by mutation, genetic drift, and natural selection. By analyzing ancient DNA, the study aims to observe evolution in action and quantify the effects of selection on phenotypic traits. The goal is to better understand the relationship between genetic ancestry and disease risk, which can help predict health outcomes across diverse populations. This research will utilize a combination of genetic analysis and demographic studies to draw conclusions about the impact of recent natural selection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a diverse genetic background, particularly those with ancestry linked to populations in Britain.
Not a fit: Patients who do not have a genetic background relevant to the populations being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors influencing disease risk, leading to improved prevention and treatment strategies.
How similar studies have performed: Previous research has shown success in using ancient DNA to understand genetic evolution and its implications for health, suggesting that this approach is promising.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mathieson, Iain Neil — University of Pennsylvania
- Study coordinator: Mathieson, Iain Neil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.