Understanding how genetic variants influence gene regulation in single cells
Mapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell types
This study is looking at how certain parts of our DNA help control how genes work in different types of cells, especially in blood vessel cells, using advanced tools to see these changes closely, and the goal is to help improve treatments for diseases by understanding these genetic factors better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10869990 on NIH RePORTER |
What this research studies
This research investigates how specific DNA elements called enhancers control gene expression in various cell types. By utilizing advanced CRISPR tools, the project aims to systematically map the connections between enhancers and target genes at a single-cell level. This involves studying how enhancer functions change during the development of vascular cells and creating computational models to predict these interactions based on chromatin accessibility. Patients may benefit from insights into the genetic factors influencing diseases, leading to better-targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates include individuals with genetic predispositions to cardiovascular diseases or other conditions influenced by enhancer-gene regulation.
Not a fit: Patients with conditions unrelated to genetic variants affecting enhancer-gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic influences on diseases, potentially guiding more effective treatments.
How similar studies have performed: Other research has shown promise in using CRISPR technologies for mapping gene regulation, indicating a strong potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Engreitz, Jesse M — Stanford University
- Study coordinator: Engreitz, Jesse M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.