Understanding how genetic variants affect immune responses in eye diseases
Modulation of immunodominance in HLA class I associated uveitides
This study is looking at how certain changes in a gene related to the immune system might affect people with eye diseases like uveitis, and it aims to find new treatments to help those who are struggling with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11018551 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variants in the ERAP1 gene influence the immune system's response to certain eye diseases, particularly uveitis. By using advanced techniques like CRISPR/Cas9 genome editing, the study aims to uncover the mechanisms by which these genetic factors can either trigger or protect against conditions like Behçet’s uveitis and acute anterior uveitis. The goal is to develop targeted therapies that can improve treatment outcomes for patients suffering from these autoimmune eye diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Behçet’s uveitis or acute anterior uveitis, particularly those with specific HLA class I alleles.
Not a fit: Patients with uveitis not associated with HLA class I alleles or those with other unrelated eye conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with autoimmune uveitis, potentially reducing the risk of blindness.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Nowatzky, Johannes — New York University School of Medicine
- Study coordinator: Nowatzky, Johannes
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.