Understanding how genetic variants affect gene regulation and disease
Official title: Statistical methods for interpretation of genetic variants by gene regulatory networks
Funded at Clemson University · NIH-10925310 · Data updated 2026-11-12
This study is looking at how certain genetic differences that don't directly code for proteins can affect how our genes work and contribute to diseases, helping us understand the links between genetics and health better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | September 8, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $357,994 |
| NIH project number | 5R35GM150513-02 |
| Project ID | NIH-10925310 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic variants linked to diseases, particularly those involving non-coding regions of the genome.
✕Less likely to help
Patients without any known genetic variants or those with conditions not influenced by genetic factors may not benefit from this research.
What this research studies
This research investigates how genetic variants in non-coding regions of the genome influence gene regulatory networks and contribute to diseases. By using advanced statistical methods, the project aims to connect these variants to their effects on gene expression and phenotypes. The approach combines expression quantitative trait locus (eQTL) mapping with gene regulatory networks (GRNs) to provide a more comprehensive understanding of genetic influences on health. This could help clarify the complex relationships between genetics and disease, particularly for variants that are not well understood.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for interpreting genetic information, enhancing personalized medicine and disease prevention strategies.
How similar studies have gone: Previous research has shown promise in using eQTL mapping and GRNs to interpret genetic variants, indicating that this approach has potential for success.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Duren, Zhana — Clemson University
- Study coordinator: Duren, Zhana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.