Understanding how genetic variants affect gene expression in different tissues and stages of development
Official title: Computational and Statistical Methods to determine variant effect across cell types and development stages
Funded at Yale University · NIH-10990741 · Data updated 2026-11-12
This study is looking at how our genes affect how our bodies work at different ages and in different tissues, and it's for anyone interested in understanding more about how genetics can influence health and disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 23, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,913,337 |
| NIH project number | 1U01HG013840-01 |
| Project ID | NIH-10990741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation would include individuals who are willing to donate biological samples and have a diverse genetic background across different developmental stages.
✕Less likely to help
Patients with conditions that do not involve genetic variants affecting gene expression may not benefit from this research.
What this research studies
This research focuses on identifying how genetic variants influence gene expression across various tissues and developmental stages, including postnatal, early childhood, pre-pubertal, and post-pubertal periods. By recruiting 120 donors, the project aims to develop advanced statistical methods to analyze the data effectively, especially given the challenges posed by fewer samples compared to previous studies. The research will utilize single-cell sequencing and hierarchical Bayesian methods to provide insights into tissue-specific and cell-type-specific gene expression. The findings will be shared with the broader research community to enhance understanding of genetic influences on health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors that influence health outcomes, potentially guiding personalized medicine approaches.
How similar studies have gone: Previous projects like the GTEx have shown success in similar approaches, indicating a strong foundation for this research.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Zhao, Hongyu — Yale University
- Study coordinator: Zhao, Hongyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.