Understanding how genetic risk factors influence brain tumor development
Official title: Investigating the impact of glioma-associated germline risk alleles on neurodevelopmental trajectories
Funded at University of Tx Md Anderson Can Ctr · NIH-11110694 · Data updated 2026-11-12
This study is looking at how certain genetic changes might make some people more likely to develop gliomas, a type of brain tumor, and it’s for anyone interested in understanding the early signs of this condition to help improve future treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $460,940 |
| NIH project number | 1R21NS142585-01 |
| Project ID | NIH-11110694 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of gliomas or those identified as having genetic risk factors for brain tumors.
✕Less likely to help
Patients without any known genetic predisposition to gliomas or those who have already been diagnosed with advanced glioma may not benefit from this research.
What this research studies
This research investigates the genetic factors that may increase the risk of developing gliomas, a type of brain tumor. By focusing on specific genetic variations known as glioma-associated risk SNPs, the study aims to understand how these variations affect the development of brain cells and potentially lead to tumor formation. The researchers will use advanced techniques, including human stem cell-derived organoids, to observe how these genetic factors influence cell differentiation and behavior. This could provide insights into the early stages of glioma development and inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new methods for early detection and prevention of gliomas, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Huse, Jason — University of Tx Md Anderson Can Ctr
- Study coordinator: Huse, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.