Understanding how genetic repeats contribute to Alzheimer's disease
Short tandem repeats as a novel genetic driver of Alzheimer's disease
This work explores how specific genetic variations, called short tandem repeats, might cause Alzheimer's disease and influence its progression.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11116861 on NIH RePORTER |
What this research studies
We know that genetics play a big role in Alzheimer's disease, but many genetic factors are still unknown. This project looks at a type of genetic variation called short tandem repeats (STRs), which are sections of DNA that are repeated many times. While STRs are known to cause other brain diseases, their connection to Alzheimer's is not well understood. This work aims to see if these STRs are linked to when Alzheimer's symptoms start and how quickly the disease progresses. We will also investigate if these STRs become unstable in brain cells of people with Alzheimer's.
Who could benefit from this research
Good fit: This foundational genetic work is relevant to individuals with Alzheimer's disease and their families, especially those with a family history of the condition.
Not a fit: Patients without Alzheimer's disease or a family history of the condition may not directly benefit from this specific genetic discovery work.
Why it matters
Potential benefit: If successful, this work could uncover new genetic causes for Alzheimer's disease, potentially leading to new ways to predict, prevent, or treat the condition.
How similar studies have performed: While STRs are known to cause other neurological diseases, their specific role in Alzheimer's disease is a new area of exploration.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Guo, Michael Haoming — University of Pennsylvania
- Study coordinator: Guo, Michael Haoming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.