Understanding how genetic mutations affect reproduction and development in birds
Official title: Genomic Conflict Resolution: Establishment of a new model for unconstrained germline selection
Funded at Rockefeller University · NIH-11033783 · Data updated 2026-11-12
This study is looking at how changes in genes from reproductive cells might cause problems in other parts of the body, which can lead to birth defects, and it uses songbirds to help us understand how these genetic changes are passed down and affect future generations.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $158,509 |
| NIH project number | 1K99HG014014-01 |
| Project ID | NIH-11033783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital disorders or those interested in genetic conditions that may have a hereditary component.
✕Less likely to help
Patients without any genetic disorders or those not affected by congenital conditions may not benefit from this research.
What this research studies
This research investigates how genetic mutations in reproductive cells can lead to conflicts with the needs of other body tissues, potentially causing congenital disorders. By using a unique genomic element found in songbirds, the study aims to create a new model for understanding germline selection and its evolutionary implications. The approach involves analyzing how these mutations are passed down through generations and their effects on offspring. This could provide insights into the mechanisms behind various genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of congenital disorders and inform strategies for prevention or treatment.
How similar studies have gone: While the specific model being proposed is novel, similar research has shown promise in understanding genetic conflicts and their implications for health.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Biegler, Matthew Theodor — Rockefeller University
- Study coordinator: Biegler, Matthew Theodor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.