Understanding how genetic mutations affect health and disease
Investigating the landscape and genetic architecture of germline mutagenesis
This study is looking at how differences in our DNA's ability to fix itself can affect the chances of getting mutations, which might lead to issues like birth defects or cancer, and it's using mice to help understand these effects better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11011052 on NIH RePORTER |
What this research studies
This research investigates how variations in DNA proofreading and repair mechanisms can influence mutation rates in both germline and somatic cells. By studying these mutations, the research aims to uncover their impact on health outcomes, such as the occurrence of birth defects and cancer risk. The approach includes analyzing genetic variants in specific mouse models to identify factors that contribute to mutation rate differences. This work could provide insights into the genetic basis of mutation rates and their implications for human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of genetic disorders or cancers, as well as those interested in understanding their genetic health risks.
Not a fit: Patients without a genetic predisposition to mutations or those not affected by conditions related to mutation rates may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors that influence disease risk, potentially guiding preventive measures and treatments.
How similar studies have performed: Previous research has shown success in understanding mutation rates and their implications in other contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Harris, Kelley — University of Washington
- Study coordinator: Harris, Kelley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.