Understanding how genetic mutations affect brain cells in schizophrenia
Modeling patient mutations in iPSC-derived neurons to reveal cellular mechanisms of schizophrenia
This study is looking at how certain genetic changes linked to schizophrenia affect brain cells, using special cells made from patients' own skin cells, to help us better understand what happens in the brain of someone with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10914053 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms of schizophrenia by modeling patient-specific mutations in neurons derived from induced pluripotent stem cells (iPSCs). Using a technique called CRISPR-interference, the study aims to knock down specific genes associated with schizophrenia to observe changes in gene expression and cellular behavior. By comparing these changes to other models of schizophrenia, the research seeks to uncover the biological underpinnings of the disorder. This approach integrates genetics and biology to provide insights into how rare genetic mutations contribute to the development of schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who have specific genetic mutations.
Not a fit: Patients without a diagnosis of schizophrenia or those without identifiable genetic mutations related to the disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of schizophrenia, potentially informing new therapeutic strategies for patients.
How similar studies have performed: Other research has shown promise in using iPSC models and CRISPR techniques to study genetic disorders, indicating that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Sunshine, Anna Brosius — University of Washington
- Study coordinator: Sunshine, Anna Brosius
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.