Understanding how genetic mutations affect a key enzyme in Alzheimer's disease
Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease
['FUNDING_R01'] · UNIVERSITY OF KANSAS LAWRENCE · NIH-10823225
This study is looking at how certain genetic changes in a protein can affect an enzyme linked to Alzheimer's disease, with the hope of finding new ways to help people with this condition in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS LAWRENCE (nih funded) |
| Locations | 1 site (LAWRENCE, UNITED STATES) |
| Trial ID | NIH-10823225 on ClinicalTrials.gov |
What this research studies
This research investigates familial Alzheimer's disease by focusing on the role of gamma-secretase, an enzyme that processes amyloid precursor proteins. It aims to understand how specific genetic mutations in presenilin proteins alter the structure and function of gamma-secretase, potentially leading to the accumulation of harmful amyloid-beta plaques in the brain. By combining chemical, structural, and computational biology techniques, the research seeks to uncover the mechanisms behind these mutations and their impact on Alzheimer's disease progression. Patients may benefit from insights gained that could inform future treatments or interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease, particularly those with known genetic mutations in presenilin proteins.
Not a fit: Patients with sporadic Alzheimer's disease without familial links or genetic mutations may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for familial Alzheimer's disease by targeting the underlying mechanisms of amyloid-beta production.
How similar studies have performed: Previous research has shown promising results in understanding the role of gamma-secretase in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
LAWRENCE, UNITED STATES
- UNIVERSITY OF KANSAS LAWRENCE — LAWRENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOLFE, MICHAEL S — UNIVERSITY OF KANSAS LAWRENCE
- Study coordinator: WOLFE, MICHAEL S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease