Understanding How Genetic Mixing Changes
The evolution and genetics of recombination rate variation
This project aims to understand how genetic mixing, or recombination, works and changes over time, which is important because errors in this process can lead to human chromosomal disorders like Down syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11159723 on NIH RePORTER |
What this research studies
Our bodies' cells mix up genetic material during reproduction, a process called recombination, and this project explores how and why this mixing varies. We are using advanced genomic tools and studying model animals like threespine sticklebacks and fruit flies to uncover the genetic and evolutionary reasons behind these variations. By understanding these fundamental processes, we hope to learn more about how errors in genetic mixing contribute to conditions such as Trisomy 21 and Klinefelter syndrome. This work could provide crucial insights into the basic patterns of genetic inheritance and the causes of certain human chromosomal disorders.
Who could benefit from this research
Good fit: This foundational research is most relevant to patients and families affected by chromosomal disorders like Trisomy 21 (Down syndrome) and Klinefelter syndrome, as it explores the basic biological mechanisms underlying these conditions.
Not a fit: Patients whose conditions are not related to errors in meiotic recombination or chromosomal abnormalities would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could deepen our understanding of the fundamental causes of human chromosomal disorders, potentially leading to new ways to prevent or address them in the future.
How similar studies have performed: This project builds upon existing knowledge by testing long-standing hypotheses with new genomic technologies, suggesting a blend of established concepts and novel experimental approaches.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Samuk, Kieran — University of California Riverside
- Study coordinator: Samuk, Kieran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.