Understanding how genetic mixing between species affects health
The population genomics of hybridization: from genetic incompatibilities to genome evolution
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11128526
This project explores how genes from different species combine and what that means for health conditions like melanoma and problems with embryo development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11128526 on ClinicalTrials.gov |
What this research studies
Researchers are looking into how genetic exchange between different species, called hybridization, shapes the genetic makeup of many living things, including humans. They are particularly interested in what happens when genes from two different species mix, which can sometimes lead to severe health issues. Using a specific fish model, the team aims to map out these problematic genetic interactions across the entire genome. The goal is to uncover the molecular reasons behind conditions like melanoma and early embryo loss that can arise from these genetic mixes.
Who could benefit from this research
Good fit: Patients with conditions like melanoma or a history of embryonic lethality, whose conditions might be linked to complex genetic interactions, could potentially benefit from future applications of this basic research.
Not a fit: Patients whose conditions are not related to genetic hybridization or the specific genetic mechanisms being studied may not directly benefit from this particular research.
Why it matters
Potential benefit: This work could help us better understand the genetic causes of diseases like melanoma and issues with embryo development, potentially leading to new ways to prevent or treat them in the future.
How similar studies have performed: This research builds upon previous findings in the lab regarding genetic consequences of hybridization and develops new computational methods, indicating a foundation of prior work in this area.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHUMER, MOLLY — STANFORD UNIVERSITY
- Study coordinator: SCHUMER, MOLLY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.