Understanding how genetic material is accurately passed from parents to children
Structural and functional principles underlying germline genome transmission
This study is looking at how genes are passed on during reproduction to understand why some pregnancies end in miscarriage or why children may have developmental issues, with the hope that the findings can help improve fertility and child health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11084406 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the accurate transmission of genetic material during reproduction, focusing on the process of homologous recombination during meiosis. By studying proteins involved in this process, the researchers aim to uncover how errors in genetic transmission can lead to conditions such as miscarriage or developmental defects in children. The study combines biochemical, structural, and biophysical methods with functional experiments to provide a comprehensive understanding of these critical biological processes. Insights gained could help improve fertility outcomes and child development.
Who could benefit from this research
Good fit: Ideal candidates for this research are families experiencing reproductive challenges, such as miscarriages or genetic disorders in children.
Not a fit: Patients who are not experiencing reproductive issues or genetic concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for reproductive issues and developmental disorders in children.
How similar studies have performed: Other research has shown success in understanding genetic transmission mechanisms, but this specific approach combining multiple methodologies is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Keeney, Scott — Sloan-Kettering Inst Can Research
- Study coordinator: Keeney, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.