Understanding how genetic issues affect pregnancy outcomes differently in males and females
Mechanisms underlying sex-dependent pregnancy outcomes caused by fetal and maternal genomic instability
This study looks at how changes in genes in mothers and their babies can affect pregnancy outcomes differently depending on whether the baby is a boy or a girl, especially focusing on how the placenta and inflammation might impact the health of female babies, with the goal of finding ways to prevent problems during pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10901862 on NIH RePORTER |
What this research studies
This research investigates how genetic instability in mothers and fetuses can lead to different pregnancy outcomes based on the sex of the fetus. It focuses on the role of the placenta and how inflammation can affect fetal health, particularly in female embryos. By studying animal models, the research aims to uncover the mechanisms that lead to adverse pregnancy outcomes and how these can be influenced by maternal genetics and environmental factors. The findings could provide insights into preventing complications during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals or those planning to become pregnant, particularly those with a family history of pregnancy complications.
Not a fit: Patients who are not pregnant or do not plan to become pregnant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing adverse pregnancy outcomes and enhancing fetal health.
How similar studies have performed: Previous research has indicated that understanding genetic factors in pregnancy can lead to significant advancements in maternal-fetal medicine, suggesting potential for success in this area.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Schimenti, John C — Cornell University
- Study coordinator: Schimenti, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.