Understanding how genetic factors influence tau protein spread in early-onset Alzheimer's disease
Neurogenetic contributions to the spread of tau pathology in sporadic early-onset Alzheimer's disease
This study is looking at how genes might affect the spread of tau-related changes in the brains of people with early-onset Alzheimer's disease, with the hope of finding better ways to care for and treat those affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10992125 on NIH RePORTER |
What this research studies
This research investigates the genetic contributions to the spread of tau pathology in early-onset Alzheimer's disease (EOAD), which is known for its aggressive clinical course and atypical symptoms. By utilizing advanced neuroimaging techniques and analyzing gene expression, the study aims to uncover the mechanisms that drive disease progression in EOAD. Patients will be part of the Longitudinal Early-onset Alzheimer’s Disease Study (LEADS), which provides a rich dataset for understanding how tau pathology develops over time. The goal is to enhance knowledge that could lead to improved patient care and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sporadic early-onset Alzheimer's disease.
Not a fit: Patients with late-onset Alzheimer's disease or other forms of dementia may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of early-onset Alzheimer's disease, potentially improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding tau pathology in Alzheimer's disease, but this specific focus on early-onset cases and genetic factors is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Katsumi, Yuta — Massachusetts General Hospital
- Study coordinator: Katsumi, Yuta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.