Understanding how genetic factors influence opioid use disorder
Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorder
This study is looking at how our genes might affect different stages of opioid use disorder, which could help us understand the condition better and find new ways to treat it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10889203 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that contribute to different stages of opioid use disorder (OUD), a condition that has become a significant public health crisis. By utilizing advanced techniques like capped small RNA sequencing, the study aims to create a detailed map of the regulatory elements and genes involved in OUD. This approach will help identify how specific genes are activated or suppressed during various phases of opioid addiction, providing insights into the biological underpinnings of this disorder. Patients may benefit from a better understanding of their condition and potential new treatment strategies based on genetic insights.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of opioid use disorder or those at risk of developing it due to genetic predispositions.
Not a fit: Patients who do not have a history of opioid use or are not genetically predisposed to opioid use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for opioid use disorder by targeting the underlying genetic factors.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Telese, Francesca — University of California, San Diego
- Study coordinator: Telese, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.