Understanding how genetic factors influence immunity to tuberculosis
Dissecting the genetic basis of protective immunity to tuberculosis in diverse hosts
This study is looking at how our genes affect how well we fight off tuberculosis and handle its effects, using mice to find new ways to boost our immune system, which could help people who struggle with current treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10879738 on NIH RePORTER |
What this research studies
This research investigates the genetic basis of how different individuals respond to tuberculosis, focusing on both resistance to the infection and the ability to tolerate its effects. By studying various mouse models that mimic human responses to TB, the research aims to identify genetic factors that contribute to effective immune responses. The goal is to uncover new strategies that could enhance the body's natural defenses against TB, especially in cases where current treatments are ineffective. Patients may benefit from insights that could lead to innovative therapies targeting the immune system rather than just the bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic tuberculosis infections or those at high risk of developing severe TB disease.
Not a fit: Patients who have not been diagnosed with tuberculosis or those with acute infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve immune responses in patients with tuberculosis.
How similar studies have performed: Previous research has shown promise in understanding genetic factors influencing immune responses in other infectious diseases, suggesting potential for success in this area as well.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Smith, Clare Margaret — Duke University
- Study coordinator: Smith, Clare Margaret
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.