Understanding how genetic factors influence blood pressure through epigenetic changes
Epigenomes and Epigenetic Mechanisms in BP-relevant Tissues
This study is looking at how certain genes, especially parts that don’t directly code for proteins, can influence blood pressure, which might help people understand their own blood pressure better and lead to new treatment options.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10903755 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that affect blood pressure, focusing on noncoding regions of DNA that are linked to hypertension. By examining how these genetic variations influence the expression of blood pressure-related genes through epigenetic mechanisms, the study aims to uncover the underlying biological processes. Patients may benefit from insights into how their genetic makeup can affect their blood pressure and potential new treatment strategies. The research employs advanced techniques like ATAC sequencing to analyze epigenomic changes across various tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of hypertension or those diagnosed with high blood pressure.
Not a fit: Patients with primary hypertension that is not influenced by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of hypertension, potentially reducing the risk of cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on blood pressure, but this approach focusing on epigenetic mechanisms is relatively novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Greene, Andrew S. — University of Arizona
- Study coordinator: Greene, Andrew S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.