Understanding how genetic factors influence blood pressure regulation
Genetic and Epigenetic Mechanisms of BP Regulation
This study is looking at how certain genes and their activity affect blood pressure, with the goal of finding new ways to help people manage high blood pressure better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10903747 on NIH RePORTER |
What this research studies
This research investigates the genetic and epigenetic factors that control blood pressure (BP), focusing on noncoding regions of DNA that are linked to BP regulation. The team will utilize precision genome editing techniques to explore how specific genetic variations affect gene expression in cells relevant to BP management. By identifying these mechanisms, the research aims to uncover new insights into how these genetic factors contribute to BP regulation and potentially lead to improved treatments for hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of hypertension or those diagnosed with high blood pressure.
Not a fit: Patients with primary hypertension not linked to genetic factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing and treating high blood pressure, benefiting patients with hypertension.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on blood pressure, but this approach focusing on noncoding SNPs is relatively novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Liang, Mingyu — University of Arizona
- Study coordinator: Liang, Mingyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.