Understanding how genetic factors influence blood clotting
Official title: Genetic architecture of tissue factor expression
Funded at Beth Israel Deaconess Medical Center · NIH-10945020 · Data updated 2026-11-12
This study is looking at how our genes influence a key protein that helps our blood clot, which could help people understand their risk for bleeding problems or blood clots.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $674,338 |
| NIH project number | 1R01HL175060-01 |
| Project ID | NIH-10945020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with a family history of bleeding disorders or thrombotic events.
✕Less likely to help
Patients with no known genetic predisposition to coagulation disorders may not benefit from this research.
What this research studies
This research investigates the genetic factors that regulate the expression of tissue factor (TF), a crucial initiator of blood coagulation. By examining variations in the F3 gene across different human tissues, the study aims to uncover how these genetic differences can lead to either excessive bleeding or increased risk of blood clots. The research employs a combination of genetic analysis and biochemical assays to identify new regulatory elements and mutations that affect TF activity. Patients may benefit from insights into their own genetic predispositions to bleeding disorders or thrombotic events.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for patients at risk of bleeding or clotting disorders.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on coagulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Schulman, Sol — Beth Israel Deaconess Medical Center
- Study coordinator: Schulman, Sol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.