Understanding how genetic factors affect the severity of flavivirus infections
Host Factors Controlling Neuroinvasive Flavivirus Pathogenesis
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10893545
This study is looking at how our genes might affect how sick we get from certain viruses, like West Nile and Japanese encephalitis, using a special group of mice to find out which genes help fight off these infections, with the hope of improving treatments for these serious diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10893545 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variations in the host can influence the severity of diseases caused by flaviviruses, such as Powassan, West Nile, and Japanese encephalitis viruses. By using a special panel of genetically diverse mice, the study aims to identify which genes are associated with resistance or susceptibility to these infections. The researchers will analyze how these viruses interact with the immune system and the resulting effects on the brain and central nervous system. This work could lead to better understanding and potential treatments for neuroinvasive diseases caused by flaviviruses.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with a history of flavivirus infections or those at high risk of exposure, such as residents in endemic areas.
Not a fit: Patients who have not been exposed to flavivirus infections or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating severe flavivirus infections in humans.
How similar studies have performed: Other research has shown success in identifying genetic factors that influence disease outcomes in viral infections, suggesting that this approach may yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAZEAR, HELEN — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: LAZEAR, HELEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene