Understanding how genetic factors affect DNA stability in stem cells
Dissecting genetic determinants of epigenetic instability in pluripotent stem cells
This study is looking at how certain genes affect the stability of DNA marks in stem cells, which are important for their ability to turn into different types of cells, and it aims to help improve how we use these stem cells in medicine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11042709 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to the instability of DNA methylation marks in pluripotent stem cells (PSCs), which are crucial for their ability to develop into various cell types. By identifying specific genetic variants that influence these epigenetic changes, the study aims to enhance our understanding of how PSCs can maintain their developmental potential. The researchers will utilize advanced genetic mapping techniques and transgenic models to explore the relationship between genetic variants and DNA methylation stability. This knowledge could lead to improved methods for using PSCs in medical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to conditions that affect stem cell function or those interested in stem cell therapies.
Not a fit: Patients who do not have any genetic conditions affecting stem cell function or who are not considering stem cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more reliable and effective use of pluripotent stem cells in regenerative medicine and therapies for degenerative diseases.
How similar studies have performed: Previous research has shown that understanding genetic influences on epigenetic stability can lead to advancements in stem cell therapies, indicating potential success for this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Stadtfeld, Matthias — Weill Medical Coll of Cornell Univ
- Study coordinator: Stadtfeld, Matthias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.