Understanding how genetic factors affect cognitive ability in brain development
Developing multimodal biomarkers of cognitive ability in a genetic model of neurodevelopment
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10890604
This study is looking at how changes in brain cells affect thinking skills in people with Rett syndrome, hoping to find clues that could help improve treatments for cognitive challenges.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10890604 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between cellular networks in the brain that contribute to cognitive abilities, particularly in individuals with Rett syndrome, a severe neurodevelopmental disorder. By examining how specific gene mutations disrupt healthy brain development, the study aims to identify biomarkers that link abnormal brain activity to cognitive impairments. The approach includes analyzing brain organoids and non-invasive EEG recordings to uncover mechanisms that may explain cognitive disabilities. Patients may benefit from insights that could lead to targeted interventions or therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Rett syndrome or similar neurodevelopmental disorders linked to genetic mutations.
Not a fit: Patients without genetic neurodevelopmental disorders or those with cognitive impairments from non-genetic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating cognitive impairments associated with genetic disorders.
How similar studies have performed: Previous research has shown promise in linking genetic mutations to cognitive outcomes, but this specific approach using multimodal biomarkers is relatively novel.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAZARES, CHRISTIAN — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CAZARES, CHRISTIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.