Understanding how genetic enhancers influence evolution and disease
Statistical and high-throughput models of enhancer function and evolution
This study is looking at how certain genetic elements called enhancers affect the way genes work and how this relates to the differences we see in various bird species and their health, helping us understand evolution and diseases better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11013972 on NIH RePORTER |
What this research studies
This research investigates the role of genetic enhancers, which are crucial for regulating gene expression, in the evolution of different species and their associated diseases. By developing statistical models, the research aims to connect changes in enhancer sequences with variations in traits and disease states across species, particularly focusing on birds. The study will also conduct large-scale functional tests of enhancers in developing bird limbs to better understand their impact on gene expression and evolution. This approach combines comparative population genomics with innovative statistical methods to provide insights into enhancer function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases influenced by enhancer function, particularly those related to limb development or cancers.
Not a fit: Patients with conditions unrelated to genetic enhancers or those not involving evolutionary aspects of gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors influencing diseases and evolutionary traits, potentially informing new therapeutic strategies.
How similar studies have performed: While the study of enhancers is a growing field, this specific approach combining statistical modeling with large-scale functional testing in birds is relatively novel.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Edwards, Scott V. — Harvard University
- Study coordinator: Edwards, Scott V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.