Understanding how genetic enhancers influence evolution and disease
Statistical and high-throughput models of enhancer function and evolution
['FUNDING_R01'] · HARVARD UNIVERSITY · NIH-11013971
This study is looking at how certain parts of our DNA, called genetic enhancers, help shape the traits of different species and their health, using birds' limb development as a model to understand how these changes can affect evolution and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11013971 on ClinicalTrials.gov |
What this research studies
This research investigates the role of genetic enhancers, which are noncoding regions of DNA that regulate gene expression, in the evolution of different species and their associated diseases. By developing statistical models, the research aims to connect changes in enhancer sequences to variations in physical traits and disease states across species. The study will also conduct large-scale functional tests of enhancers using the limb development of birds as a model, providing insights into how these genetic elements contribute to evolution and health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or diseases linked to enhancer function, as well as those interested in evolutionary biology.
Not a fit: Patients with conditions unrelated to genetic enhancers or those not interested in the evolutionary aspects of genetics may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors influencing diseases and evolutionary traits, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown success in understanding enhancer function and its implications in evolution, but this approach of linking phylogenetic patterns with phenotypic variation is relatively novel.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EDWARDS, SCOTT V. — HARVARD UNIVERSITY
- Study coordinator: EDWARDS, SCOTT V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer