Understanding how genetic enhancers influence evolution and disease
Statistical and high-throughput models of enhancer function and evolution
This study is looking at how certain parts of our DNA, called genetic enhancers, influence the traits and health of different bird species, helping us understand how these changes can affect both their development and the diseases they might face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10767241 on NIH RePORTER |
What this research studies
This research investigates the role of genetic enhancers, which are noncoding regions of DNA that regulate gene expression, in the evolution of different species and their associated diseases. By developing statistical models, the research aims to connect changes in enhancer sequences with variations in physical traits and disease states across species, particularly focusing on birds. The study will also conduct large-scale functional tests of enhancers using the limb development of both flying and flightless birds as a model. This approach will help clarify how genetic changes impact phenotypic evolution and disease susceptibility.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders or cancers that may be influenced by enhancer function.
Not a fit: Patients with conditions unrelated to genetic enhancers or those not affected by genetic variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors influencing diseases, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding enhancer function and its implications for evolution and disease, suggesting that this approach has potential for significant insights.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Edwards, Scott V. — Harvard University
- Study coordinator: Edwards, Scott V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.