Understanding how genetic elements control gene activity
Interpretable Computational Models of Functional Genomics Data
This study is exploring how certain parts of our DNA work together to control gene activity and how genes can be switched on or off in different ways, which could help us understand more about health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-10884224 on NIH RePORTER |
What this research studies
This research focuses on deciphering the complex interactions of cis-regulatory elements (CREs) that influence gene transcription and alternative splicing. By utilizing advanced computational techniques, particularly deep convolutional neural networks (CNNs), the project aims to predict how these regulatory elements work together in the context of DNA sequences. The researchers will develop methods to interpret these predictions, making it easier to understand the biological significance of the findings. This could lead to new insights into genetic regulation and its implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions related to transcription and splicing abnormalities.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by transcriptional or splicing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation, potentially leading to improved treatments for genetic disorders.
How similar studies have performed: Other research has shown promise in using computational models to understand genetic regulation, indicating that this approach could yield valuable insights.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Koo, Peter K — Cold Spring Harbor Laboratory
- Study coordinator: Koo, Peter K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.