Understanding how genetic elements affect immune aging in sepsis
Official title: Role of Transposable Elements in Septic Immune Aging
Funded at University of California, San Francisco · NIH-11033397 · Data updated 2026-11-12
This study is looking at how certain genetic elements might affect the immune response in older people with sepsis, a serious infection, to better understand why their immune systems may not work as well and how this could impact their recovery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $190,278 |
| NIH project number | 1K08GM157557-01 |
| Project ID | NIH-11033397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have experienced sepsis or are at risk of developing it.
✕Less likely to help
Patients who are younger than 21 years old or those without a history of sepsis may not benefit from this research.
What this research studies
This research investigates the role of transposable elements (TEs) in the immune response of older individuals suffering from sepsis, a severe infection-related condition. It aims to understand how the de-repression of these genetic elements can lead to accelerated aging of the immune system, potentially worsening outcomes in sepsis. By studying immune cells and their responses, the research seeks to uncover the mechanisms behind age-related immune decline and how it relates to sepsis severity. Patients may be involved in providing samples or data to help elucidate these complex interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and interventions for older patients suffering from sepsis, enhancing their immune response and survival rates.
How similar studies have gone: Previous research has shown that understanding the role of genetic elements in immune responses can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Perez, Alexendar Reinaldo — University of California, San Francisco
- Study coordinator: Perez, Alexendar Reinaldo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.