Understanding how genetic disease risks change over time and among different populations
Official title: Evolution of genetic disease risks over time and space
Funded at Georgia Institute of Technology · NIH-10673157 · Data updated 2026-11-12
This study is looking at how the risks of genetic diseases have changed over time by examining DNA from both ancient and modern people, especially from groups that haven't been studied much before, to help create better health tools for everyone, no matter their background.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 5, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $376,117 |
| NIH project number | 5R35GM133727-05 |
| Project ID | NIH-10673157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from underrepresented populations in genetic studies, particularly those with diverse ancestral backgrounds.
✕Less likely to help
Patients with genetic conditions that are well-studied and have established risk factors may not receive additional benefit from this research.
What this research studies
This research investigates the evolution of genetic disease risks by analyzing both ancient and modern genomes. It aims to bridge the gap between evolutionary genetics and genetic epidemiology, focusing on diverse populations that have been underrepresented in previous studies. By utilizing mathematical modeling and computer simulations, the project seeks to identify how hereditary disease risks vary across different ancestries and to develop tools that can enhance precision medicine for individuals from diverse backgrounds. The findings could lead to improved predictions of hereditary disease risks and better health outcomes for various populations.
Why it matters
Potential benefit: If successful, this research could provide more accurate assessments of genetic disease risks for individuals from diverse ancestries, leading to tailored prevention and treatment strategies.
How similar studies have gone: Previous research has shown success in using genomic approaches to understand disease risks, but this project aims to explore novel aspects that have not been extensively tested.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Lachance, Joseph L. — Georgia Institute of Technology
- Study coordinator: Lachance, Joseph L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.