Understanding How Genetic Differences Cause Diseases
Statistical methods and analyses to study genetic variants and their roles in diseases leveraging functional genomics data.
['FUNDING_OTHER'] · DARTMOUTH COLLEGE · NIH-11135557
This project is creating new computer tools to help us understand how tiny differences in our genes can lead to various diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-11135557 on ClinicalTrials.gov |
What this research studies
Many common diseases are linked to small differences in our genes, but it's often hard to tell exactly which genetic changes are responsible and how they cause problems. This project is building advanced computer methods to sort through huge amounts of genetic information, including data from individual cells. We want to find the specific genetic variations that lead to diseases and understand how they affect our cells and body tissues. This will help us connect genetic findings to the actual ways diseases develop.
Who could benefit from this research
Good fit: This foundational work does not involve direct patient participation, but its findings will ultimately benefit individuals living with a wide range of genetic diseases.
Not a fit: Patients seeking immediate clinical interventions or direct participation in a treatment trial would not find this particular foundational research directly beneficial.
Why it matters
Potential benefit: This work could lead to a much clearer understanding of what causes many diseases, which is a crucial step toward developing new treatments and prevention methods.
How similar studies have performed: This project aims to develop novel statistical methods to address critical gaps in current approaches for connecting genetic variants to diseases.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, SIMING — DARTMOUTH COLLEGE
- Study coordinator: ZHAO, SIMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.