Understanding how genetic differences and viral infections influence blood diseases in children
Dissecting the role of germline genetic variation and viral exposures as determinants of hematological disease predisposition
['FUNDING_R03'] · VAN ANDEL RESEARCH INSTITUTE · NIH-10871295
This study is looking at how genes passed down from parents and certain viral infections might play a role in causing blood diseases like acute myeloid leukemia (AML) in kids, with the goal of finding ways to help prevent and treat these conditions.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VAN ANDEL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (GRAND RAPIDS, UNITED STATES) |
| Trial ID | NIH-10871295 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic variations inherited from parents and viral infections may contribute to the development of blood diseases, particularly acute myeloid leukemia (AML) in children. The study aims to explore the interaction between these genetic factors and viral exposures, focusing on how they may lead to structural changes in DNA that increase the risk of leukemia. By analyzing these relationships, the research seeks to uncover potential risk factors that could inform prevention and treatment strategies for pediatric blood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with acute myeloid leukemia or those with a family history of blood diseases.
Not a fit: Patients with blood diseases unrelated to genetic factors or viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for blood diseases in children, potentially reducing the incidence of conditions like acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic and viral factors in adult cancers, but this specific focus on pediatric blood diseases is relatively novel.
Where this research is happening
GRAND RAPIDS, UNITED STATES
- VAN ANDEL RESEARCH INSTITUTE — GRAND RAPIDS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRICHE, TIMOTHY J. — VAN ANDEL RESEARCH INSTITUTE
- Study coordinator: TRICHE, TIMOTHY J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.