Understanding how genetic differences affect tolerance to chromosome abnormalities in yeast
Dissecting the influence of genetic background on aneuploidy tolerance in the model eukaryote Saccharomyces cerevisiae
This study is looking at how different genetic backgrounds in yeast can affect their ability to handle having an unusual number of chromosomes, which might help us understand similar situations in human health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10891652 on NIH RePORTER |
What this research studies
This research investigates how variations in genetic backgrounds influence the ability of yeast cells to tolerate aneuploidy, which is the presence of an abnormal number of chromosomes. By using the model organism Saccharomyces cerevisiae, the researchers will systematically manipulate yeast chromosomes to observe how different strains respond to these changes. The study aims to uncover the genetic mechanisms that allow some yeast strains to thrive despite having extra chromosomes, which could provide insights into similar processes in human health and disease.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with cancers characterized by aneuploidy or those facing challenges related to genetic disorders.
Not a fit: Patients with conditions unrelated to aneuploidy or those not affected by genetic variations in chromosome tolerance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how genetic factors contribute to cancer and drug resistance, potentially informing new treatment strategies.
How similar studies have performed: While the study of aneuploidy in yeast is established, the specific approach of manipulating genetic backgrounds to assess tolerance is innovative and may yield novel insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Gasch, Audrey — University of Wisconsin-Madison
- Study coordinator: Gasch, Audrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.