Understanding how genetic differences affect the severity of cryptococcal infections
Natural genomic variants that influence cryptococcal pathogenicity
This study is looking at the genetic differences in a fungus that can cause serious infections in people with HIV, to help us understand how these differences affect how sick someone might get and how we can improve their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10876484 on NIH RePORTER |
What this research studies
This research investigates the natural genomic variants of the fungus Cryptococcus neoformans, which causes severe infections, particularly in individuals with HIV. By analyzing strains collected from patients with cryptococcal meningitis, the researchers aim to identify specific genetic differences that influence how virulent these strains are. The study combines genetic and genomic techniques with experimental validation to uncover the molecular mechanisms behind these variations. Ultimately, this research seeks to improve our understanding of how these genetic factors affect disease progression and patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cryptococcal meningitis, particularly those who are HIV-positive.
Not a fit: Patients with cryptococcal infections who do not have identifiable genetic variants or those without HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted treatments for cryptococcal infections, potentially reducing mortality rates in vulnerable populations.
How similar studies have performed: Previous research has shown promise in understanding the genetic factors influencing fungal virulence, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Doering, Tamara L — Washington University
- Study coordinator: Doering, Tamara L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.