Understanding how genetic differences affect the safety and effectiveness of certain cancer and antiviral drugs.
Pharmacogenetics of Nucleobase and Nucleoside Analog Drugs
This study is looking at how differences in your genes might affect how well certain cancer and virus-fighting medications work for you and whether you experience side effects, so we can create safer and more personalized treatment plans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11026431 on NIH RePORTER |
What this research studies
This research investigates how genetic variations influence the response and side effects of nucleobase and nucleoside analog drugs, which are used in treating cancer and viral infections. By studying the NUDT15 gene, the research aims to identify why some patients experience severe adverse effects while others do not. The approach includes analyzing genetic data and developing clinical guidelines to tailor drug dosing based on individual genetic profiles. This could lead to safer and more effective treatments for patients requiring these medications.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing treatment with nucleobase and nucleoside analog drugs for cancer or viral infections, particularly those with a history of adverse reactions.
Not a fit: Patients who are not receiving nucleobase or nucleoside analog drugs or those without genetic variations affecting drug metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of severe side effects from nucleobase and nucleoside analog drugs, improving patient safety and treatment outcomes.
How similar studies have performed: Previous research has successfully identified genetic factors influencing drug metabolism, suggesting that this approach could yield valuable insights and improvements in treatment safety.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Yang, Jun J. — St. Jude Children's Research Hospital
- Study coordinator: Yang, Jun J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.