Understanding how genetic differences affect susceptibility to Zika virus
Official title: Human Genetic Variation Regulating Cellular Susceptibility to Zika Virus
Funded at Duke University · NIH-11096079 · Data updated 2026-11-12
This study is looking at how our genes might affect how we respond to Zika virus infections, especially in people of African descent, to help find ways to better protect those at risk of serious health issues from the virus.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $200,269 |
| NIH project number | 5R21AI185498-02 |
| Project ID | NIH-11096079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of African descent or those with a family history of severe Zika virus outcomes.
✕Less likely to help
Patients who are not of African descent or those who have not been affected by Zika virus may not receive direct benefits from this research.
What this research studies
This research investigates the role of human genetic variation in determining how individuals respond to Zika virus infections. By examining genetic differences among people, particularly those of African descent, the study aims to identify specific alleles that may influence susceptibility to the virus and its severe outcomes, such as congenital Zika syndrome. The approach includes genome-wide association studies and in vitro experiments using cells from individuals with different genetic backgrounds. This research could lead to better understanding and potentially personalized treatments for those at risk of severe Zika virus outcomes.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to targeted prevention strategies and treatments for individuals at higher risk of severe Zika virus infections.
How similar studies have gone: While there have been successful studies on genetic susceptibility to other viral infections, this specific approach to Zika virus is novel and has not been extensively tested.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Ko, Dennis Chun-Yone — Duke University
- Study coordinator: Ko, Dennis Chun-Yone
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.