Understanding how genetic differences affect malaria vaccine development
Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine Candidates
This study is looking at how different versions of the malaria parasite might affect how well new vaccines work, especially for kids, by analyzing genetic information from people who are infected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10873926 on NIH RePORTER |
What this research studies
This research investigates the impact of genetic diversity in the malaria-causing parasite, Plasmodium falciparum, on the effectiveness of potential vaccines. By using advanced genomic techniques, the study aims to identify and analyze specific antigens that could be targeted by vaccines. The approach involves collecting genomic data from infected patients to better understand how variations in these antigens influence immune responses. This could lead to the development of more effective malaria vaccines, particularly for vulnerable populations such as children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11, particularly those living in malaria-endemic regions.
Not a fit: Patients who are not affected by malaria or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the creation of more effective malaria vaccines, significantly reducing malaria-related deaths in children.
How similar studies have performed: Previous research has shown promise in using genomic approaches to identify vaccine candidates, suggesting that this method could lead to significant advancements in malaria vaccine development.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Bei, Amy Kristine — Yale University
- Study coordinator: Bei, Amy Kristine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.