Understanding how genetic differences affect inflammation in patients
Official title: From genetic variants to mechanisms: understanding drivers of inflammation
Funded at Vanderbilt University Medical Center · NIH-11095994 · Data updated 2026-11-12
This study is looking at how our genes affect our immune system and cause different levels of inflammation, with the hope of finding better, personalized treatments for chronic inflammatory diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | June 5, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $437,500 |
| NIH project number | 5R35GM155339-02 |
| Project ID | NIH-11095994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory diseases with a suspected genetic component.
✕Less likely to help
Patients with acute inflammatory conditions or those without a genetic predisposition to chronic inflammation may not benefit from this research.
What this research studies
This research investigates the complex interactions within the immune system and how genetic variations among individuals can lead to different inflammatory responses. By analyzing these genetic variants, the study aims to uncover the underlying mechanisms that drive chronic inflammatory diseases. The approach includes advanced bioinformatics tools and cellular assays to identify specific gene variants that contribute to these conditions. Ultimately, the goal is to pave the way for personalized therapies that target the root causes of inflammation rather than using broad immunosuppressive treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for chronic inflammatory diseases.
How similar studies have gone: Previous research has shown promise in understanding genetic influences on immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Markle, Janet G — Vanderbilt University Medical Center
- Study coordinator: Markle, Janet G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.