Understanding how genetic differences affect inflammation in patients
From genetic variants to mechanisms: understanding drivers of inflammation
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11095994
This study is looking at how our genes affect our immune system and cause different levels of inflammation, with the hope of finding better, personalized treatments for chronic inflammatory diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11095994 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions within the immune system and how genetic variations among individuals can lead to different inflammatory responses. By analyzing these genetic variants, the study aims to uncover the underlying mechanisms that drive chronic inflammatory diseases. The approach includes advanced bioinformatics tools and cellular assays to identify specific gene variants that contribute to these conditions. Ultimately, the goal is to pave the way for personalized therapies that target the root causes of inflammation rather than using broad immunosuppressive treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory diseases with a suspected genetic component.
Not a fit: Patients with acute inflammatory conditions or those without a genetic predisposition to chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for chronic inflammatory diseases.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARKLE, JANET G — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: MARKLE, JANET G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.