Understanding how genetic differences affect human traits and fitness
Function and fitness consequences of human genetic variation
This study is looking at how differences in our DNA can change how our genes work and how proteins are made, which might impact our health and how we adapt over time, especially focusing on groups of people who haven't been studied much before.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10842587 on NIH RePORTER |
What this research studies
This research investigates how variations in DNA sequences influence gene expression and protein function, which may affect human health and evolutionary fitness. The team will utilize advanced computational and statistical methods to analyze genomic data from diverse human populations, particularly focusing on those underrepresented in previous studies. By examining RNA sequencing data and linking it to DNA variations, the research aims to uncover the mechanisms that drive differences in gene expression and their implications for health and evolution.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals from diverse genetic backgrounds, particularly those of non-European ancestry.
Not a fit: Patients with no genetic variation or those with conditions unrelated to genetic expression may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors that influence health and disease, potentially informing personalized medicine approaches.
How similar studies have performed: Previous research has shown success in understanding genetic variation and its impact on health, but this study aims to address gaps in representation and knowledge, making it a novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Mccoy, Rajiv Champion — Johns Hopkins University
- Study coordinator: Mccoy, Rajiv Champion
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.