Understanding how genetic differences affect heart cell recovery after injury
Sequence Variants Impacting Cardiomyocyte S-phase Activity in Inbred Mice Following Injury
This study is looking at how certain genes affect heart cells' ability to heal after a heart attack, using specially modified mice to find out which genes help the heart recover better, with the hope of finding new treatments for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10758952 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations influence the ability of heart cells to recover and regenerate after a heart injury, specifically myocardial infarction. By studying different strains of mice, the researchers aim to identify genes that enhance heart cell activity during recovery. The approach involves creating genetically modified mice and observing their heart cell behavior following induced injuries. This could lead to insights into potential therapies for improving heart recovery in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to heart disease or those who have experienced a myocardial infarction.
Not a fit: Patients with heart conditions unrelated to genetic factors or those who have not experienced a myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart recovery after injuries, potentially improving outcomes for patients with heart disease.
How similar studies have performed: Previous studies have shown that manipulating genetic factors can successfully enhance heart cell recovery, suggesting this approach has potential for success.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Field, Loren J — Indiana University Indianapolis
- Study coordinator: Field, Loren J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.