Understanding how genetic differences affect drug metabolism
Expression genetics of pharmacogenes
This study is looking at how our genes affect how we process medications, especially focusing on certain enzymes that handle most drugs, to help figure out why some people respond differently to treatments and to create more personalized medicine for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11057569 on NIH RePORTER |
What this research studies
This research investigates how genetic variations influence the metabolism of drugs in the body, focusing on cytochrome P450 enzymes that are responsible for processing about 70% of medications. By examining the genetic factors that lead to differences in drug metabolism, the research aims to identify biomarkers that can predict how individuals will respond to specific drugs. The study employs innovative methodologies to explore the complex genetic architecture of these enzymes and their regulatory mechanisms, which could lead to more personalized and effective drug therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are prescribed medications that are metabolized by cytochrome P450 enzymes and may have varying responses to these drugs.
Not a fit: Patients who do not take medications metabolized by cytochrome P450 enzymes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized drug therapies that are safer and more effective for patients.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on drug metabolism, indicating that this approach could yield significant insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Wang, Danxin — University of Florida
- Study coordinator: Wang, Danxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.