Understanding how genetic differences affect cell behavior and development
Cellular Systems Genetic Approaches to Understanding Regulatory Variation
['FUNDING_OTHER'] · JACKSON LABORATORY · NIH-11011864
This study is looking at how natural differences in our genes can affect the way our cells develop and function, which might help us understand why some people have health issues later in life, especially by using stem cells to see how these genetic variations influence cell behavior.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-11011864 on ClinicalTrials.gov |
What this research studies
This research investigates how natural genetic variations influence the biology of chromatin, which is crucial for cell fate and the diversity of physical traits. By focusing on regulatory elements that control gene expression, the study aims to uncover how disruptions in these elements during early development can lead to long-term health issues. Using advanced cellular systems genetics, the research employs stem cells to model how genetic variability affects chromatin modifications and ultimately impacts cell identity and differentiation. This approach leverages the diversity found in mammalian genetics to provide insights into the relationship between genetics and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of developmental disorders or diseases linked to genetic variations.
Not a fit: Patients with conditions unrelated to genetic regulatory variations or those who do not have a genetic predisposition to developmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors that contribute to various diseases, potentially informing new treatment strategies.
How similar studies have performed: Other research has shown promising results in understanding genetic variations and their impact on health, indicating that this approach is building on established findings.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAKER, CHRISTOPHER LEE — JACKSON LABORATORY
- Study coordinator: BAKER, CHRISTOPHER LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.