Understanding how genetic differences affect blood cell development
Investigating the Impact of Epigenetic Heterogeneity on Hematopoiesis
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF WASHINGTON · NIH-11015775
This study is looking at how the unique genetic features of blood stem cells affect their ability to turn into different types of blood cells, which could help us understand more about blood-related diseases and how blood cells are formed.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11015775 on ClinicalTrials.gov |
What this research studies
This research investigates how variations in the genetic makeup of hematopoietic stem cells (HSCs) influence their ability to develop into different types of blood cells. By examining the epigenetic factors that contribute to these differences, the study aims to uncover how these variations affect the cells' lineage decisions and overall function. The researchers will analyze the epigenetic states of individual HSCs to determine how these states impact their potential to differentiate into specific blood cell types. This work could provide insights into the fundamental processes of blood cell formation and the implications for blood-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders or cancers that affect blood cell production.
Not a fit: Patients with non-hematological conditions or those not affected by blood cell-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders and cancers by enhancing our understanding of blood cell development.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics in cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WONG, MADELINE — UNIVERSITY OF WASHINGTON
- Study coordinator: WONG, MADELINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.