Understanding how genetic differences affect a key Alzheimer's gene
Regulatory variation that affects splicing of the Alzheimer's disease risk gene TREM2
This project looks at how small changes in our genes might affect a specific gene called TREM2, which is linked to Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11197608 on NIH RePORTER |
What this research studies
Alzheimer's disease is a serious health challenge, and its frequency is growing as people live longer. While age and genetics are known to play a big role, we don't fully understand all the genetic factors involved. This project focuses on genetic variations that don't change proteins directly but instead affect how genes are 'read' or 'spliced,' especially a gene called TREM2. TREM2 is important for brain immune cells, and certain changes in it are strongly linked to Alzheimer's risk. By understanding these genetic differences, we hope to learn more about what causes Alzheimer's and potentially find new ways to help.
Who could benefit from this research
Good fit: This foundational genetic research is not directly recruiting patients but aims to benefit individuals at risk for or living with Alzheimer's disease, especially those with genetic predispositions like APOE e4 or TREM2 variants.
Not a fit: Patients whose Alzheimer's disease is not linked to genetic factors or TREM2 gene variations may not directly benefit from this specific line of genetic inquiry.
Why it matters
Potential benefit: If successful, this work could uncover new genetic targets for developing treatments or preventative strategies for Alzheimer's disease.
How similar studies have performed: While the role of TREM2 in Alzheimer's is established, this specific focus on regulatory variations affecting its splicing represents a novel and less explored area of genetic investigation.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Korvatska, Olena — University of Washington
- Study coordinator: Korvatska, Olena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.